Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams
نویسندگان
چکیده
منابع مشابه
Transannular Diels-Alder reaction on macrocycles. A general strategy for the synthesis of polycyclic compounds
Various aspects of the transannular Diels-Alder reaction are examined in order to eventually develop a general method for the synthesis of a large variety of polycyclic compounds related to the diterpenes, mterpenes and steroids. Emphasis is made on the control of the relative and absolute configuration of the polycyclic products. Preliminary work towards the synthesis of some specific target n...
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The first transannular [4 + 2] cycloaddition reactions of macrocyclic dicobalt hexacarbonyl-dienyne complexes were demonstrated. Complexes were conveniently prepared through palladium(II)-catalyzed intramolecular oxidative cyclization of bis(vinylboronate esters) followed by complexation with dicobalt octacarbonyl. Transannular [4 + 2] cycloaddition reactions of the complexes occurred at lower ...
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Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized. The construction of macrocycles is generally considered as a crucial and challenging step in the synthesis of macrocyclic natural products. Over the last several decades, numerous efforts have been underta...
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Over the past several years, the prevalence of biologically active macrocycles in medici nal chemistry literature has been increasing. Numerous recent review articles have dis cussed the role that macrocycles can play in medicinal chemistry, in particular looking beyond the established importance of natural product macrocycles in drug discovery [1–3]. Driggers et al. have argued that macrocyc...
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Two configurational isomers of bis-urea macrocycles have been synthesized, and their neutral molecule recognition was studied by X-ray crystallography and (1)H NMR experiments. Cooperative action between the deep cavity and the urea groups and the influence of dipole alignments on molecular recognition are discussed.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2008
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol802729f